Abstract
Five hundred μg vitamin A was given daily for 2 weeks, and the amounts of the vitamin in feces, liver and blood were determined. It was found that the amount of the vitamin in feces and that in serum remained roughly the same without showing any tendency to increase. Therefore the saturation with the vitamin is not to be concluded from the finding of fecal vitamin. On the contrary, the amount of the vitamin in liver rose definitely. Twenty four hours after feeding 500μg vitamin A, the vitamin content in all organs was determined and a marked rise was found only in the liver. The vitamin found was only 22%, including the amount excreted in feces. The loss was 78% in 24 hours. After 100-400mg α-tocopherol was added to 1000μg vitamin A, the rise in the amount of the vitamin in liver was insignificant. The rise in vitamin A in serum and liver was determined at intervals after feeding a single dose of 1000μg vitamin A, and the highest value was obtained in 15 hours in liver and 3 hours in serum.
