STUDIES ON SUBSTANCES OF THE TOXOPYRIMIDINE GROUP : (XVIII) THE RUNNING FIT INCITING ACTION OF HYDROXYLAMINE AND THIOSEMICARBAZIDE

Abstract

The glutamic acid, glutamic decarboxylase activity, γ-aminobutyric-α-ketoglutaric transaminase activity and γ-aminobutyric acid during the running fit incited by carbonyl reagents (hydroxylamine, thiosemicarbazide) were measured quantitatively. It was found that glutamic acid and γ-aminobutyric acid are reduced and the two enzymes are inhibited both in in vitro and in vivo experiments. The results suggest that the running fit incited by carbonyl reagents is identical with that induced by 2-methyl-4-amino-5-hydroxymethylpyrimidine.