STUDIES ON INTERMEDIARY METABOLISM RELATED TO COENZYME A AND ITS DERANGEMENT IN PATIENTS AND ANIMALS WITH LIVER DAMAGE : (II) INFLUENCE OF THE TREATMENT IN PATIENTS WITH CHRONIC LIVER DISEASES

Abstract

Abnormal increase in urinary α-keto acids following fructose loading was less marked after the simultaneous administration of cocarboxylase or calcium pantothenate. Treatment using cocarboxylase or calcium pantothenate improved the disturbance of α-keto acid metabolism and the acetylation in these patients. Methionine was also effective in improving disturbance in α-keto acid metabolism.