Abstract
The administration of a large amount of thiamine, dibenzoylthiamine or cocarboxylase to rats by feeding or intraperitoneal injection for three months did show no decrease of riboflavin in the carcases. Namely, for the control test 40μg each of thiamine, riboflavin, and pyridoxine per rat per day were supplied through the diet consisting of 18% casein, 67% starch, 10% fat, 4% mineral, and 1% cod liver oil, but for the test group thiamine or its analogous was given 10 times as much that in the control test. After three months of the administration, the distribution of thiamine and riboflavin in liver, kidney, heart, muscle and blood were examined. It was observed that there was no significant difference of thiamine and riboflavin contents comparing with the control test except higher thiamine content in liver of rats fed thiamine or its analogous.
