Abstract
The effect of dosed various acids on the urinary excretion of L-ascorbic acid was investigated. The effect was found to be related to the blood content of ascorbic acid. When the blood level of ascorbic acid was 0.6-0.8 mg%, the effect of acids on the excretion was so little as the control. But when the same doses of acids were administered to subjects saturated with ascorbic acid, the urinary excretion of ascorbic acid, increased markedly. Organic acids, such as citric and acetic acid, produced a marked increase in the excretion of ascorbic acid, but HCl and NaHCO_3 had only a slight influence. In addition, the effect of the same acids on the urinary excretion of various acids was measured, and it was noted that these results were different from the result of ascorbic acid. This observation is of considerable interest since it suggests the possibility of the difference of mechanism between the effect of acids on ascorbic acid excretion and the acid base balance in the body.
