Abstract
Choline content in the blood was determined in various diseases and its change by medical treatments was observed. The average choline content in the blood of 38 healthy subjects was 20.2±1.25mg/dl, and no differences were found between male and female, or young and old. The choline content in the blood was high in bronchial asthma, jaundice, chronic glomerulonephritis and leucemia, while it was low in tuberculous diseases, sepsis, gastritis, gastroduodenal ulcer, splanchnoptosis, colitis, dysentery, cirrhosis of liver, neuropathy, anemia, endocrinism, avitaminosis and acute toxicosis. It was found that the determination of choline content in the blood was useful for the judgement of hepatic and posthepatic jaundice, and in the latter the choline content was over 25 mg/dl in every case. The administration of thiamine, riboflavin, nicotinic acid or insuline, blood trasfusion or mixing of blood in vitro, caused a decrease of choline content in the blood while the administration of multivitamin preparation, ATP or lipotropic factor or X-ray irradiation caused its increase.
