Abstract
Rats and mice of about 80g and 12g respectively were fed on a diet containing various amounts of riboflavin for 50 days, and weight gain, urinary excretion and the amounts of the vitamin in organs and tissue respiration of the organs were estimated. When 15 μg of riboflavin was administered daily to rats, riboflavin-deficiency occurred. The maximum riboflavin content of the whole body was observed at the 30th day of a daily administration of more than 400 μg of the vitamin. Even though much more amount of riboflavin was given, the length of time needed for the maximum level could not be shortened. By the administration of riboflavin, the amount of the vitamin in the liver, kidney and heart greatly increased, while in the lung only a slight increase was observed.
