Abstract
Aureomycin, Chloromycetin and Achromycin were administered orally on normal children for 7 days, and thiamine level of blood, fecal and urinary excreation were determined daily. The urinary excreation of thiamine once increased and then decreased in the case of Aureomycin and Achromycin administration. On the other hand it was increased by Chloromycetin. The fecal excreation of thiamine remarkably decreased immediately after antibiotics administration. Disturbance of thiamine metabolism was observed after 7 days' administration of the autibiotics by thiamine loading test. On the contrary thiamine level of blood was kept almost constant during this period and thiamine deficient signs were not found clinically.
