Abstract
The intestinal amines of biological origin were experimentally proved to have toxicity for the liver, and when some disorders had occurred in the process of transaction of the amines in vivo, the toxicity increased. The author assumed that such liver disorders possibly occurred based on metabolic disturbances of a certain vitamin B-complex (thiamine, riboflavin, nicotinic acid, vitamin B_6,choline, etc.), particularly vitamin B_6. Concerning histamine, it has been reported that coenzyme of oxidizing enzyme of histamine is vitamin B_6 or riboflavin. According to our previous experiment, it seemed to be very possibile that vitamin B_6 might be coenzyme of histaminase, and investigations on the influence of amines of biological origin, especially of histamine, on the deficiency of vitamin B_6 were performed.
