Abstract
Since orotic acid and its related compounds were expected to be the precursors of the uridine diphosphate glucuronic acid formation, the effects of these compounds on glucuronide conjugation in rats were investigated. After parenteral administration of orotic acid, uridine or uridine monophosphate, with or without propylene glycol as an aglycone for the conjugation, the urinary excretion of total and conjugated glucuronic acid in 24 hours was determined according to Fishman's method. These compounds showed no effect on the endogenous glucuronide formation. One point five per cent of administered propylene glycol was excreted through the conjugation, which showed no increase by the administration of orotic acid and the related compounds.
