Abstract
In 1952,M. Fujiwara and T. Watanabe discovered allithiamine, a new derivative of thiamine. Since this compound was synthesized by T. Matsukawa and S. Yurugi, many kinds of thiamine derivatives have been prepared. However, no systematic studies have been made on the effects of these substances on the growth of microorganisms. Then, an investigation was carried out on the growth of L. fermenti in the existence of disulfide derivatives such as thiamine allyl-, propyl-, methyl-, ethyl-, tetrahydrofurfuryl- and 2-hydroxyethyl disulfides with an interesting result that the growth activities of these substances were more remarkable than that of thiamine hydrochloride.
