Abstract
The thiamine contents of various organs of rats which died 2 to 4 days or were killed one week after the Pneumoccocus infection, were compared to those of 3 days or one week after the Aureomycin administration. A marked changes were found in the heart, followed by liver, kidney and spleen. The pathological transformations were found in these organs. In the case of 3 days administration of 50 mg per kg per day of Aureomycin, the thiamine contents of the organs were almost unchanged, even increased in the one week administtration. The reduction of thiamine content by Pneumococcus infection is provably due to the pathological changes. It is postulated that the change of thiamine content by Aureomycin may be due to the prevention of pathological changes and to the metabolic hyperfunction by restoration mechanism.
