STUDIES ON THIAMINE DISULFIDE : (II) BIOLOGICAL PROPERTIES OF O-BENZOYLTHIAMINE DISULFIDE

Abstract

In the course of studies on thiamine disulfide we found that a new derivative, O-benzoyl thiamine disulfide (BTDS) is easily absorbed into organisms. BTDS exerts thiamine activity approximately equivalent to that of thiamine hydrochloride in a thiamine requring organism, rice bird and rat. BTDS is readily absorbed in the human body as well as in rabbit and rat, by oral administration and consequently the blood thiamine levels, the thiamine contents of organs and blood cocarboxylase activity rise remarkably and the risen levels last for a long time.