Abstract
From the fact that pantothenic acid tends to be mobilized in the brain when it is given from the outside and it is also known to be widely distributed in the organs, it was assumed that if the β-alanine moiety was replaced with γ-aminobutyric acid, transfer to the brain would be greater compared to γ-aminobutyric acid. γ-Aminobutyric acid, α-and β-hydroxy-γ-aminobutyric acid and their pantoyl-bound forms were prepared and comparative studies were conducted on the effect on various types of seizures, inhibition of excitability and prolongation of sleep. It was found that compared to γ-aminobutyric acid or its hydroxyl derivatives, the pantoyl- or carbobenzoxy derivative had a stronger action. Homopantothenic acid especially, had a pronounced and stable action and moreover, it completely suppressed the running fit induced by hydroxymethylpyrimidine.
