Abstract
As significant increases of thiamine in urine, blood, and various tissues were observed in normal persons as well as in the normal or thiamine deficient rats by the oral administration of O-benzoylthiamine disulfide, it was oraly administered in patients with dermatosis whose blood level of thiamine was lower than normal, and clinical improvements were observed. Of 38 patients, improvements were noted in 9 cases (23%) by daily administration of 30mg for 3 to 4 weeks. Disturbed liver functions were also improved at the same time in 7 cases (31.8%) out of 22 cases.
