Abstract
About solubilization of vitamins A and D, some phenomena were clarified and some new methods were developed. To find out optimal surfactant to prepare the stable aqueous solutions of vitamins A and D, required HLB values of the surfactants for solubilization of various kinds of vitamins A and D were measured. Clouding formation of aqueous solution of vitamins A or D solubilized with nonionic surfactants relates to the structure of the solubilizate and solubilizer. Irritating action of the aqueous solution of solubilizer when injected to a muscle depends upon the structure of the solubilizer. Sucrose esters or raffinose esters were used for solubilization instead of polyoxyethylene derivatives. The structure of vitamin Acholeic acid (Galosterin) is so-called inclusion type, and this is one method to solubilize vitamin A in aqueous alkaline solution.
