STUDIES ON OROTIC ACID : (IV) THE EFFECT OF OROTIC ACID ON NITROGEN BALANCE AND WEIGHT OF ORGANS IN OPERATIVE STRESS

Abstract

In albino rats fed on synthetic diet and a nonprotein diet, the administration of orotic acid supressed the decrease in body weight caused by the operative stress. The postoperative negative nitrogen balance on the protein depleted rats was remarkably improved by the administration of orotic acid and it was revised more evidently by the addition of orotic acid to all amino acids than the latter only. The postoperative edema of organs in the rats was improved by the adminstration of orotic acid. In rats reared on the synthetic diet containing 100mg of orotic acid per 100g for 100 days, fatty liver was not observed patho-histologically.