Abstract
The author intended to investigate systematically, the vitamin B_<12> absorption and its urinary excretion under endocrine disorders, using Wistar strain rats which were administered ^<60>Co-labeled vitamin B_<12> intragastrically or subcutaneously. The results obtained in normal rats were as follows : When 0.05 μg of B_<12>-^<60>Co was given intragastrically, the intestinal absorption amounted to 66.4±4.6% with male but to 39.8±1.0% (P<0.05) with female. The urinary excretions were 3.32±0.49% and 3.86±0.66%. The uptake by liver was 4.23% and 4.38%, and the renal uptake was 4.09% and 4.71% respectively. Co-administration of saline extract of gastric mucosa of Wistar strain rats as source of intrinsic factor with B_<12>-^<60>Co, enhanced the intestinal absorption up to 70.7±1.5% in male rats i. e. an increase being not significant. After subcutaneous administration of 0.04 μg of B_<12>-^<60>Co in male rats, intestinal excretion measured by feces amounted to 16.3±0.5%. The urinary excretion was 3.82±0.55%, and the uptake by liver and kidney was 7.01 and 8.47% respectively.
