1963 Volume 28 Issue 6 Pages 508-516
The present authors examined the radioactive substances in urine after intravenous injection of lipoic acid-^<35>S to healthy men. About 10 radioactive substances were detected on actigram and radioautogram. The radioactivity of injected lipoic acid-^<35>S was almost recovered in 24 hours urine. Sulfate-^<35>S was small in urine. Amoung 10 radioactive substances, Rf 0.1,0.6 and 0.75 (developed with water-saturated n-butanol) were main products (about 32% of the total activity). Rf 0.6 and 0.75 substances responded for Streptococcus faecalis R or Coryne-bacterium bovis, which are thought to be conjugated forms of lipoic acid, and free lipoic acid was small as 0.3% of the administered amount.
