Abstract
CoQ, which is one of cafactors of the terminal oxidation system in liver cells, was measured by spectrophotometric method of Morton et al., using column chromatography. Acute CCl_4 poisoning caused a significant decrease of CoQ content of fresh liver in rats, whereas such decrease could not be found in chronic CCl_4 poisoning. In the intracellular distribution of CoQ, it is localized mainly in the mitochondrial fraction. The amounts of CoQ in the mitochondria of acute and chronic CCl_4 poisoned livers remarkably decreased compared with normal liver. It was found that rat liver contains mainly CoQ_9,although small amount of CoQ_7,CoQ_8 and CoQ_<10> are detected by paperchromatography in the mitochondrial fraction. Hepatic content of CoQ in cadavers had no difference between sex, young and old nor with and without liver diseases.
