Abstract
It is well known that peripheral neuropathy is one of the common complications of diabetes mellitus. In such patients the increased threshold of vibratory perception in fingers and toes which estimated by biothesiometer as same as other abnormal signs and subjective symptoms were frequently observed. Pantethine, which is a derivative of pantothenic acid with β-mercaptoethylamine, was used for the treatment of diabetic neuropathy. The administration of this compound for 20 to 70 days produced an improvement in vibratory perception as well as patellar tendon reflex and subjective symptoms such as pain and parasthesia of extremities. The increasing ratio of urinary excretion of pyruvate following fructose loading was also decreased by such a treatment in these patients.
