Abstract
Acceleration of fermentation system seems to be one of the probable causes for growth-inhibition of Saccharomyces carlsbergensis at the presence of thiamine. To clarify this, fermentation-stimulating activity of modified thiamine compounds, of which growth-inhibitory effects on the yeast were studied previously (Vitamins 30,358,1964), was determined after Atkin et al.. Among disulfide-type thiamines TPD, the most effective growth-inhibitor, stimulated CO_2 evolution as much as thiamine, while BTDS with no growth-inhibitory effect showed no stimulation. Among S-acyl-type thiamines BTMP showed rather weaker stimulation compared to thiamine but DBT was weaker than BTMP in stimulating fermentation. Some of the antithiamines and pyrimidine or thiazole moieties of thiamine were all ineffective on fermentation. With exception of antithiamines, the more inhibitory on the growth of Sacch. carlsbergensis, the more stimulative on fermentation. Consumption of glucose and production of aloohol per dry weight of cells were also stimulated at the presence of thiamine.
