Abstract
The formation of thiaminic acids through the oxidation of thiol-type thiamine derivatives was investigated in more details. The oxidation of O-benzoylthiamine disulfide with hydrogen peroxide was proved to be the most effective in the lower fatty acid such as formic, acetic or propionic acid as well as their aquous solution, in the experimental condition of about 40℃ for 2-3 days. When about five-fold equivalent of the oxidants was used, the yield was approximately 50 per cent. This results indicated that more than one mole of the thiaminic acid was produced from one mole of the disulfide. Further, it was observed that the thiaminic acid was also obtainable by the oxidation with bromine, permanganate or bichromate, but the yield was lower than that of hydrogen peroxide oxidation.
