STUDIES ON THIAMINE MONOPHOSPHATE DISULFIDE : (III) BIOLOGICAL AND PHARMACOLOGICAL PROPERTIES

Abstract

Biological and pharmacological studies were made on thiamine monophosphate disulfide (TMPDS). In thiamine deficient rats, TMPDS exerted the thiamine activity approximately equivalent to that of thiamine hydrochloride. Administration of TMPDS to dogs resulted in long retention of thiamine in high blood concentration together with the increased blood cocarboxylase activity lasting for a long duration. TMPDS exhibited the analgesic activity nearly equal to that of aminopyrine. In rabbits TMPDS produced moderate falls of blood pressure with little influence on respiration. Myocardial activity was depressed in the heart isolated from frogs. Peristaltic movement was stimulated in the intact intestine of rabbits. Acute toxicity in mice was much lower than that of thiamine hydrochloride. TMPDS was definitely resistant to thiaminase I and II produced by Bacillus thiaminolyticus and B. aneurinolyticus.