Abstract
Some biological and pharmacological properties of O-butyroylthiamine disulfide (BuTDS) were studied. BuTDS showed thiamine activity approximately equivalent to that of thiamine hydrochloride in thiamine deficient rats. The thiamine levels and the cocarboxylase activities of blood in dogs and in rabbits at intraveneous or intramuscular administration rose remarkably and its higher level was maintained for a long time. BuTDS produced moderate falls of blood pressure and depressed slightly the respiration of rabbit and myocardial activity of isolated heart of frog. The tension and the peristalisis of isolated intestines of rabbit decreased by BuTDS, while those of intact intestines increased. Acute toxicity of BuTDS in mice was much lower than that of thiamine hydrochloride.
