Abstract
Experiments were performed to determine the nutritional interrelationship between hepatic CoA and dietary protein or some essential amino acids in young rats. Rats were given either 18% casein diet (standard diet) or 5 % casein diet (low protein diet) during 4 weeks. Body weight and total hepatic CoA of the standard diet group were markedly increased throughout the feeding period, but such a tendency was not found in low protein diet group. The concentration of hepatic CoA in standard diet group was higher than that of low protein diet during the first 2 weeks of feeding, thereafter, it was observed that the concentration of CoA in low protein diet group was increased at the 4th week. In the next, young rats were divided into 7 groups ; standard, low-protein, control, methionine-deficiency, lysine-deficiency, tryptophan-deficiency and threonine-deficiency diet groups. The hepatic CoA concentration was reduced as compared with control when the methionine deficiency diet was administered for 10 days. The effect of lysine and tryptophan deficiency on hepatic CoA concentration was slight and threonine deficiency was hardly effected the hepatic CoA concentration.
