Abstract
Absorption studies of α-lipoic acid-^<35>S and its derivative, thiamine-8-(methyl-6-acetyldi-hydrothioctate) disulfide (TATD), labeled in the portion of α-lipoic acid with ^<35>S were carried out using a everted sack method of isolated rat intestine. α-Lipoic acid absorption was more rapid than that of TATD at the beginning of the reaction until 45 minutes, while after that the both absorption rates were almost same. TATD which was transported from mucosa to serosa side of intestinal segments was splitted to lipoic acid and thiamine moieties of the compound and the lipoic acid was partly converted to β-lipoic acid and an unknown compound responding to Corynebacterium bovis, not to Streptococcus faecalis. α-Lipoic acid absorption was markedly high compared with that of thiamine hydrochloride, but the absorption rate of thiamine part of TATD was stimulated five times as much as that of thiamine-HCl and became a half of absorption of lipoic acid part of TATD.
