Abstract
The effects of thiosemicarbazide (TSC) were studied during the postnatal development in the mouse. From the behavioral-and electroencephalographical (EEG) examinations, lower threshold and longer latent period of the first convulsions were observed in the younger mice treated with TSC.A running fit which was not accompanied with EEG seizure discharge was never observed in the young mice, until the EEG pattern showed the similar to that of the adult. Other several antagonists of vitamine B_6 which induce running fit as well as convulsions showed the same tendency. However, the uptake of TSC into the brain seemed to be no significant differences between the young and the adult from the results of the macroautoradiographic examination. Pyridoxal phosphate could not prevent the convulsions and the tremor in the young, while pyridoxin hydrochloride could do so. Influence of TSC in mice at the various ages was discussed, related to the brain development.
