Abstract
The intestinal absorption of 6-O-mono-lauroyl ascorbic acid (6-Lau_1-AsA) was studied in vitro using the intestinal loop of rabbit. In vivo experiments were also carried out in which 6-Lau_1-AsA had been administered orally to rabbit and the ester or its degradation products, lauric and ascorbic acids, appeared in the blood were estimated. 6-Lau_1-AsA was determined gas-liquid chromatographically according to the method described in our previous report. Available evidence obtained from both in vitro and in vivo experiments suggested that 6-Lau_1-AsA is hydrolyzed into ascorbic and lauric acids before absorbed by the intestine. 6-Lau_1-AsA itself may be impermeable through the intestine.
