Abstract
The effect of penicillamine (PeA) administration on the distribution of B_6 vitamers in mouse liver was investigated. Both DL-and D-PeA reduced markedly the contents of PLP and PMP. Effect of D-form was weaker than DL-form. The PeA administration induced an appearance of thiazolidine derivative of PL (PL-T) in response to the reduction of PLP and PMP, but the total amount of B_6 vitamers was significantly decreased. When PeA was injected along with PN, the treatment induced a marked increase of PL-T, thiazolidine derivative of PLP (PLP-T), and PNP. From the present results, it may be postulated that a depletion of PLP and PMP by the PeA treatment is attributed to the conversion from PLP to PLP-T in liver, and that the derivative is dephosphorylated to PL-T, followed by elimination of PL-T from the liver tissue.
