Abstract
The multivitamin preparation (NK-014, Nippon Kayaku Co. Ltd.) reported by Okuda et al. was tried for a clinical use in 31 children who were treated with total parenteral nutrition. A clinical effect was shown in respect to changes in plasma vitamin A, E, and 25-OH-D level. 1 . Plasma vitamin A and E levels were generally elevated after the administration of the multivitamin. Normal level was restored in 17 of 20 children with low plasma vitamin A levels, and in 15 of 19 with low plasma vitamin E levels. None was shown in abnormally high level in vitamin A and E during the period of examination, especially in the infants of less than one year of life. 2. After the administration, changes in plasma 25-OH-D_2 levels were generally shown in a slight elevation, while 25-OH-D_3 levels were in a slight decrease. Thus, total 25-OH-D levels remained unchanged in a lower level throughout the ad-ministration. In individual infants of less than one year of age, no abnormally elevated levels were shown. 3. Of 31, only one with leukemia suffered from urticaria immediately after the administration which was recovered after the remove.
