Abstract
ADP-ribosylation is a group of posttranslational modifications of proteins that have regulatory functions in the cell. In particular, poly(ADP-ribosyl) action or poly (ADP-ribose) synthesized on protein proved to play important roles in DNA repair, carcinogenesis, cell differentiation, and cell cycle events. Recent progress in the research of this variety of biological roles is reviewed on the basis of structure and function of poly (ADP-ribose) synthetase as revealed by molecular cloning techniques and by use of specific inhibitors.
