Abstract
Serum total PL and PLP concentrations were investigated in 97 adult patients with NIDDM by the HPLC method. The mean total PL and PLP concentrations in NIDDM were significantly lower than those of healthy controls. Forty-nine percent of the diabetic patients had concentrations of total PL below the mean value of the controls minus 1 SD. The insulin-treated patients had on average a lower serum total PL than those with either drug therapy or diet therapy. There were a statistical correlation between serum CPR and total PL. The mean total PL concentrations below 10% of HbA_1. With the reduction of HbA_1 after therapy, the total PL concentrations tended to increase. These results suggest that B_6 relates to discase statis of diabetics.
