Abstract
Effect of cinchomeronic acid (pyridine-3,4-dicarboxylic acid; CA) on the growth of various microorganisms, Lactobacillus plantarum, Escherichia coli (3 strains), Bacillus subtilis and Saccharomyces cerevisiae, was investigated. As the results, growth-promoting effect was observed in the each E. coli strain. Most remarkable growth-promoting effect was observed in E. coli B at 0.1-100 mM of CA. The decarboxylation of C-3 or C-4 of CA was investigated by incubating [3,4,7,8-^<14>C]CA with the cell-free extract from E. coli B was analyzed with radio-HPlC. No radioactive peak except CA was detected on this analysis. Hence, CA may promotes the growth of E. coli strains without being metabolized into other compounds.
