Abstract
An experiment was conducted with growing rats to investigate the effects of 0.1% myo-inositol, 0.1% p-aminobenzoic acid and 0.1% _<DL>-α-lipoic acid in food for 13-14 days on serum and liver lipids, liver thiobarbituric acid reactive substances (TBA-RS) and activity of serum glutamate-pyruvate transaminase (GPT) in rats fed 0.1% 1, 1, 1-trichloro-2, 2-bis(p-chlorophenyl)ethane(DDT). Feeding of myo-inositol and p-aminobenzoic acid significantly depressed the increase in serum activity of GPT due to DDT intake. In addition, the increases in liver weight, liver total lipids, liver cholesterol, liver triglyceride and serum phospholipid due to DDT feeding were suppressed by dietary addition of myo-inositol. These results suggest that dietary myo-inositol and p-aminobenzoic acid are important for animals exposed to xenobiotics such as DDT.
