Inhibitory Effect of Retinyl Acetate on the Peroxidation of Linoleic Acid with Potassium Bromate and Reduced Glutathione

Abstract

Potassium bromate (KBrO_3), a food additive, induces lipid peroxidation in the presence of reduced glutathione (GSH). Oxygen uptake and conjugated diene in the linoleic acid micelle solution relatively increased by the addition of KBrO_3 and GSH. These increases were inhibited with a singlet oxygen quencher, sodium azide or β-carotene, respectively, and similarly inhibited with retinyl acetate. But the decrease of retinyl acetate by KBrO_3 and GSH was not inhibited with sodium azide or β-carotene. These results suggest that retinyl acetate inhibited the peroxidation of linoleic acid with KBrO_3 and GSH by the scavenging of glutathione thiyl radical produced from GSH.