VITAMINS
Online ISSN : 2424-080X
Print ISSN : 0006-386X
The Role and Action of Vitamin K on Bone Metabolism
Kuniko HARAYasuhiro AKIYAMA
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JOURNAL FREE ACCESS

2003 Volume 77 Issue 9 Pages 527-535

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Abstract
Recent studies have suggested that vitamin K deficiency influences not only blood coagulation system but also bone metabolism. To prevent fracture, higher vitamin K intake may be required than to maintain the blood coagulation system. Currently, among vitamin K_2 homologues, MK-4 is used to treat osteoporosis in clinical practice. It has been reported that MK-4 inhibits bone resorption, and promotes bone formation in in vitro systems. In animal experiments, the results of histological evaluation also supported the above findings. Furthermore, the effects of MK-4 on bone mineral content (BMC) and bone strength were compared using several animal models. As a result, MK-4 not only improved bone strength in response to BMC, but also improved bone strength without affecting BMC in some models. In a clinical study, it has been reported that MK-4 is more effective for reducing the incidence of fracture than for improving bone mineral density These results suggest that MK-4 may improve bone quality.
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© 2003 THE VITAMIN SOCIETY OF JAPAN

この記事はクリエイティブ・コモンズ [表示 - 非営利 - 改変禁止 4.0 国際]ライセンスの下に提供されています。
https://creativecommons.org/licenses/by-nc-nd/4.0/deed.ja
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