Abstract
Oxidative stress during aging, which is caused by the imbalance between reactive oxygen species (ROS) generation and antioxidant defense, leads to many physiological dysfunctions. Senescence is speculated to be mediated by ROS-induced oxidative damage through chronic oxidative stress experienced over a long period during aging, so that this study has carried out to clarify whether oxidative stress implicates in neurodegeneration especially cognitive decline during aging, and whether vitamin E prevents the changes that occur during brain aging. The results revealed that when young rats were subjected to oxidative stress, their physiopathological, biochemical and behavioral changes were observed similarly to phenomena observed in normal aged rats. It was found that vitamin E inhibits markedly these abnormalities caused by oxidative stress and aging.
