Abstract
Osteoporosis is a major public health issue. In animal models of osteoporosis, antioxidant vitamins E and C have been reported to inhibit the reduction in bone density and improve the balance between bone resorption and formation, and also to enhance bone formation and increase bone strength in normal animals. Human epidemiological and intervention studies have also reported that these vitamins inhibit the reduction in bone density or reduce the risk of bone fracture in the elderly, postmenopausal women, and smokers. This review focuses on the recent findings on the association between oxidative stress and bone metabolism, and the effects of vitamin E on bone metabolism.
