Abstract
Deficiency of vitamin D due to an insufficient intake of vitamin D and lack of sunshine exposure in childhood leads to diseases caused by vitamin D deficiency such as hypocalcemic seizures, rickets, infantile convulsion, bowlegs, short stature, and developmental motor skills disorder. Recently, the number of patients with vitamin D deficiency has been increased with changes in environmental factors. However, there are many cases of vitamin D deficiency which cannot be explained by the environmental factors alone. We have analyzed the genetic predisposition for the onset of vitamin D deficiency and have found differences in the polymorphisms or haplotypes of VDR, GC, and NADSYN1 genes in patients with vitamin D deficiency. Thus, genetic factors may predispose to vitamin D deficiency to some extent. Therefore, it has been thought that further examination is needed for establishment of tailor-made intake of vitamin D in the future.
