レチナール由来エナミン型Schiff塩基を発色団とする 非共有結合型チャネルロドプシンの開発

沖津 貴志; 松山 武; 山下 高廣; 石塚 徹; 八尾 寛; 今元 泰; 七田 芳則; 和田 昭盛

doi:10.20632/vso.91.7_426

Alternative Formation of Red-Shifted Channelrhodopsins: Noncovalent Incorporation with Retinal-Based Enamine-Type Schiff Bases and Mutated Channelopsin

Takashi Okitsu, Take Matsuyama, Takahiro Yamashita, Toru Ishizuka, Hiromu Yawo, Yasushi Imamoto, Yoshinori Shichida, Akimori Wada

Author information

Takashi Okitsu
Department of Organic Chemistry for Life Science, Kobe Pharmaceutical University; Kobe
Take Matsuyama
Retinal Regeneration Lab, RIKEN Center for Developmental Biology; Kobe
Takahiro Yamashita
Department of Biophysics, Graduate School of Science, Kyoto University
Toru Ishizuka
Department of Developmental Biology and Neuroscience, Graduate School of Life Sciences, Tohoku University
Hiromu Yawo
Department of Developmental Biology and Neuroscience, Graduate School of Life Sciences, Tohoku University
Yasushi Imamoto
Department of Biophysics, Graduate School of Science, Kyoto University
Yoshinori Shichida
Department of Biophysics, Graduate School of Science, Kyoto University
Akimori Wada
Department of Organic Chemistry for Life Science, Kobe Pharmaceutical University; Kobe

Keywords: channelrhodopsin, chromophore, red-shift, neuroscience, optogenetics

JOURNAL FREE ACCESS

2017 Volume 91 Issue 7 Pages 426-429

DOI https://doi.org/10.20632/vso.91.7_426

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