皮膚送達を企図するメナヒドロキノン-4（活性型ビタミンK2（20））のプロドラッグによりビタミンK2（20）の光不安定性と光毒性の克服が可能となる

後藤 将太朗; 瀬戸口 修一; 山川 博文; 渡瀬 大輔; 寺田 一樹; 土岐 衣梨奈; 松永 和久; 加留部 善晴; 髙田 二郎

doi:10.20632/vso.94.2_71

Prodrugs for Skin Delivery of Menahydroquinone-4,an Active Form of Vitamin K₂₍₂₀₎, Could Overcome the Photoinstability and Phototoxicity of Vitamin K₂₍₂₀₎

Shotaro Goto, Shuichi Setoguchi, Hirofumi Yamakawa, Daisuke Watase, Kazuki Terada, [in Japanese], Kazuhisa Matsunaga, Yoshiharu Karube, Jiro Takata

Author information

Shotaro Goto [Japan]
Faculty of Pharmaceutical Sciences, Fukuoka University [Japan]
Shuichi Setoguchi [Japan]
Faculty of Pharmaceutical Sciences, Fukuoka University [Japan]
Hirofumi Yamakawa [Japan]
Faculty of Pharmaceutical Sciences, Fukuoka University [Japan]
Daisuke Watase [Japan]
Faculty of Pharmaceutical Sciences, Fukuoka University [Japan]
Kazuki Terada [Japan]
Faculty of Pharmaceutical Sciences, Fukuoka University [Japan]
[in Japanese]
Faculty of Pharmaceutical Sciences, Fukuoka University [Japan]
Kazuhisa Matsunaga [Japan]
Faculty of Pharmaceutical Sciences, Fukuoka University [Japan]
Yoshiharu Karube [Japan]
Faculty of Pharmaceutical Sciences, Fukuoka University [Japan]
Jiro Takata [Japan]
Faculty of Pharmaceutical Sciences, Fukuoka University [Japan]

Keywords: menaquinone-4, prodrug, phototoxicity, photostability, skin application

JOURNAL OPEN ACCESS

2020 Volume 94 Issue 2 Pages 71-74

DOI https://doi.org/10.20632/vso.94.2_71

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