Abstract
Vitamin K is generally known as a coenzyme for γ-glutamylcarboxylase (GGCX) and involved in blood coagulation and bone formation. In recent years, various new effects of vitamin K such as an agonist of nuclear receptors, an inhibitor of proliferation of liver cancer cells, and protection of neurons against oxidative stress have discovered. From these findings, derivatives of vitamin K have been synthesized and examined to obtain higher biological activities than natural vitamin K. This article introduces the recent findings of these derivatives.
