Abstract
Vitamin K is known to be a cofactor for gamma-glutamyl carboxylase and has recently been revealed to have a variety of biological activities, including agonist effects on nuclear receptors and protection of brain neurons from oxidative stress. Based on this background, studies on vitamin K derivatives have been conducted to create compounds with enhanced theses effects. In this paper, the derivatives focusing on the nuclear receptor SXR (steroid and xenobiotic receptor) and the differentiation of brain neural stem cells into neurons are mainly introduced.
