Crystal Structure of Epalrestat Non-Solvate

Abstract

The crystal structure of epalrestat non-solvate (C₁₅H₁₃NO₃S₂) was determined by X-ray crystallography. The compound crystallized in a triclinic system and was characterized as follows: P1, a = 8.20888(15)Å, b = 11.6639(2)Å, c = 16.3107(3)Å, α = 96.5985(8)°, β = 93.8393(8)°, γ = 104.6780(8)°, Z = 4, V = 1493.22(5)ų. Neighboring epalrestat molecules formed intermolecular hydrogen bonds between the carboxyl group and the carbonyl group of the rhodanine ring and the cyclic structure from four molecules.