Crystal Structure of 2,8-Bis(trifluoromethyl)-4-vinylquinoline

Abstract

The X-ray crystal structure of 2,8-bis(trifluoromethyl)-4-vinylquinoline, a key intermediate in the synthesis of potent antimalarial agents, has been established. It crystallizes in the monoclinic space group P2₁/c with cell parameters a = 16.678(2)Å, b = 17.492(7)Å, c = 8.286(4)Å, β = 97.50(2), V = 2396.5(16)ų and Z = 4. The crystal structure was refined to final values of R1 = 0.1043 and wR2 = 0.2207. An X-ray crystal structure analysis revealed that each molecule features intermolecular C–H···F hydrogen bonds and halogen halogen-type I interactions.