Part 1
Crystal Structure of Gramicidin S Hydrochloride at 1.1 Å Resolution
2019 年 35 巻 p. 1-2
詳細
2019 年 35 巻 p. 1-2
Gramicidin S hydrochloride [cyclic(–Val–Orn–Leu–d-Phe–Pro–)2·2HCl] was crystallized in the space group P21212 with cell parameters a = 34.988(1)Å, b = 23.381(1)Å, c = 18.8662(5)Å, V = 15433(1)Å3 and Z = 8. The diffraction data were collected at 1.1 Å resolution. The structure refinements converged at R = 0.165. Two independent peptide molecules were found, which formed antiparallel-sheets having intramolecular hydrogen bonds between Val and Leu residues. The peptides turned at the d-Phe–Pro moieties, and the conformations were defined as type II’ β-turn. Adjacent molecules formed an angle of 49° and were arranged side-by-side to form a β-sheet along the c-axis.
