Abstract
A 23 year-old female developed anorexia nervosa, with weight loss and anorexia. CBC revealed leucopenia, and bone marrow biopsy specimen revealed hypocellular and deposition of gelatinous material. These hematological abnormalities are primarily caused by malnutrition, however, the precise mechanism remains unknown. Endocrinological study revealed decreased plasma levels of insulin-like growth factor 1 (IGF-1) and leptin, and increased levels of growth hormone (GH), and cortisol. Since these hormones of IGF-1 and leptin are reported to have the receptors for the hematopoietic stem cells, the suppression of hematopoiesis in anorexia nervosa might be related in a part to decreased levels of these hormones. The pharmaco and psycotherapy brought the increases in the body weight and leukocyte count after 3 months.
