Short Communication
Emergence of Nalidixic Acid Resistance in Shigella sonnei Isolated from Patients Having Acute Diarrheal Disease: Report from Eastern Province of Saudi Arabia
2004 Volume 57 Issue 3 Pages 116-118
Details
2004 Volume 57 Issue 3 Pages 116-118
During the 5 years of the study period (October 1999 - October 2003), 110 strains of Shigella were isolated from fecal samples of patients having acute diarrheal diseases. Shigella sonnei phase 1 was the most prevalent (88/110, 80.0%) serotype. Resistance to nalidixic acid was not encountered from 1999 - 2002. Nalidixic acid resistance was observed in 6/13 (46.1%) of the S. sonnei phase 1 strains isolated from April - August 2003. Minimum inhibitory concentration to nalidixic acid among these strains was 48 - 96 μg/ml. All the six nalidixic acid resistant strains of S. sonnei phase 1 had reduced susceptibility (MIC 0.25 μg/ml) to ciprofloxacin.
