Abstract
Fasted rats (F1) were refed (R1) with a high fat (olive or corn oil) and high protein diet, a high fat and protein free diet or a fat free and high protein diet, then fasted again (F2) and refed (R2) with a fat free diet. The periods of fasting and refeeding were 2 days. The inductions of glucose-6-phosphate dehydrogenase and malic enzyme in R2 were significantly lower in the rats fed the high fat and high protein diet previously (R1) than in the others, and lower in corn oil-fed rats than in olive oil-fed rats. The inductions in those rats fed the protein free diet in R1 was very high and not different between corn- and olive-oil fed groups. The similar effects were observed in these rats treated with 8-azaguanine during R1. It is suggested that the high fat diet containing protein, induces “repressor-like” system to code synthesis of glucose-6-phosphate dehydrogenase and malic enzyme in rat liver. Corn oil seems to induce “repressor-like” system more actively than olive oil. The similar results were observed in acetyl-CoA carboxylase, but the enzyme activity in R2 was not significantly different by fat.
